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KMID : 0363420070210020169
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Journal of Korean Oriental Pediatrics
2007 Volume.21 No. 2 p.169 ~ p.184
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Effects of Hanghaedan on the Cytokine Secretory Function of Monocytes of Atopic Dermatitis Patients
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Lee Jin-Yong
Kim Woo-Yeoun
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Abstract
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Objectives: The late research tendency on atopic dermatitis is mainly focused on the experiment of unbalance of cytokine released from T cell subtype.
Methods: As there’s no experiment with herbal medicine using Hanghaedan(HHD), we isolated and cultured monocytes of atopic dermatitis pateints (AD) peripheral blood, for knowing the influence of HHD on the secretory function of IL-4, IL-5, $IFN-{\gamma}$.
Results: 1. In AD group, HHD exhibits statistically significant inhibitory effect on IL-4(p<0.05). 2. In AD group, HHD exhibits statistically significant inhibitory effect on IL-5(p<0.05). 3. In AD group, HHD exhibits statistically significant inhibitory effect on $IFN-{\gamma}$ (p<0.01). 4. Sample group comparing with the cytokine concentration rate value of AD patients and that of NAD patients IL-4 of AD patients exhibits statistically significant decrease(p<0.05). 5. In AD group, there is no significant relation between serum IgE and cytokines. 6. In AD group, there is no significant relation between total eosinophil and IL-5.
Conclusion: Effects of Hanghaedan on the cytokine(IL-4, IL-5, $IFN-{\gamma}$) secretory function of monocytes of atopic dermatitis patients is recognized.
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KEYWORD
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Hanghaedan, atopic dermatitis, IL-4, IL-5, $IFN-{\gamma}$
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